Opioid-like antidepressant poisoning people, CDC warns; What is tianeptine?


Researchers at The Atlanta-based Centers for Disease Control and Prevention have issued a warning about the federally-unapproved antidepressant tianeptine.

>> Read more trending news 

Poison control centers across the United States reported an increased number of calls between 2014-2017, “suggesting a possible emerging public health risk,” CDC researchers wrote in the agency’s Morbidity and Mortality Weekly Report.

According to the report, there were 11 relevant calls made to poison control centers between 2000 and 2014, but more than 200 calls made between 2013-2017.

>> Related: Major depression diagnoses in US up 33 percent since 2013, study finds

Tianeptine, which has been approved in Europe, Asia and Latin America, is “an atypical tricyclic drug” or “opioid receptor agonist.”

It was discovered and patented in the 1960s by the French Society of Medical Research, which found tianeptine to be beneficial against symptoms of anxiety and depression. In 2014, research published in the journal Translational Psychiatry noted the drug’s opioid-like behaviors.

>> Related: People with depression are more likely to use certain words — here’s how they express themselves

“In light of the ongoing U.S. opioid epidemic, any emerging trends in drugs with opioid-like effects raise concerns about potential abuse and public health safety,” CDC researchers wrote in the report.

While the Food and Drug Administration has not approved the drug, it can be purchased online as a dietary supplement or research chemical. But researchers note that two recent deaths in the U.S. have been attributed to “tianeptine toxicity” after the medication was purchased on the internet.

>> Related: Doctors and the opioid crisis: An AJC National Investigation

Abuse of the drug may lead to withdrawal symptoms similar to opioid toxicity and withdrawal. There have also been reports of vomiting, confusion, kidney failure, coma and, in some cases, death, CNN reported.

Of the calls made to poison control centers between 2014 and 2017, most tianeptine exposures resulted in moderate outcomes, including neurologic, cardiovascular and gastrointestinal signs and symptoms.

>> Related: Is it safe to take ketamine for severe depression?

The rise in calls in recent years “likely reflects the tip of the iceberg in an emerging picture of misuse and abuse of this antidepressant,” Dr. Robert Glatter, an emergency physician at New York’s Lenox Hill Hospital, told CNN. “But it also reflects the trend in patients searching for alternative medications to replace opiate painkillers in the midst of tightening of policies related to opiate prescribing.”

>> Related: Opioids now kill more Americans than guns or breast cancer, CDC says

CDC researchers note some limitations to their study, including voluntarily reported data, unintentional coding errors and limited clinical information.


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