New tests, including blood check, could help doctors diagnose autism

A newly developed blood and urine test could potentially detect autism in young children.

>> Read more trending news 

That’s according to new research from scientists in the United Kingdom and Italy who conducted tests in search for damage to proteins previously known to be higher in children with autism spectrum disorders.

The study, published this week in the academic journal Molecular Autism, tested 38 children between 5-12 years old with autism and 31 without, looking for differences in samples of urine and blood between the two groups.

The results revealed that children with autism had greater protein damage when examining plasma in their blood, which causes higher levels of an oxidation marker called ditryosine, as well as sugar-modified compounds known as advanced glycation end-products.

>> Related: Atlanta resources for those on the autism spectrum

"We have found that the power of measuring damaged proteins to the brain may be a cause for a development of autism," Dr. Paul Thornalley, professor of systems biology at the University of Warwick and one of the study’s lead researchers, explained to CNN.

According to Thornalley, previous research has also shown a connection between autism and proteins that were not damaged, the reverse of this study.

"Our discovery could lead to earlier diagnosis and intervention. We hope the tests will also reveal new causative factors," Dr. Naila Rabbani, another lead researcher from the University of Warwick, told The Guardian.

"With further testing we may reveal specific plasma and urinary profiles – or 'fingerprints' – of compounds with damaging modifications. This may help us improve the diagnosis of ASD and point the way to new causes of ASD,” she said.

While the new results appear promising, some researchers have expressed caution about the study’s small sample size and the study’s lack of a concrete diagnosis plan.

"This study may give us clues about why autistic people are different but it does not provide a new method for diagnosis. It is far too early for that," Dr. James Cusack, director of science at the UK autism research charity Autistica, told the BBC.

>> Related: 'Sesame Street' welcomes Julia, new character with autism

"We don't know whether this technique can tell the difference between autism, ADHD, anxiety or other similar conditions. The study also only looked at a small group of people," he pointed out. "The best way to diagnose autism is still through clinical interview and observation."

But despite the criticism, the scientists behind the research are calling it a "first step" toward developing a simple test. They aim to move forward with further research, performing the tests on a larger group including younger children.

"We have the method, we have everything. All we need to do is repeat it," Rabbani said. "I would really like to go forward with younger children, maybe two years, or even one year old. Then the next step will be to validate in a larger cohort. Then the tests will be ready for screening."

>> Related: Girls with autism more likely to have younger siblings with autism 

More than 3.5 million people in the U.S. currently live with autism spectrum disorders, according to statistics from the Autism Society. The development disorder, which mainly affects social interaction and leads to behavioral problems, is estimated to have genetic causes in 30 percent of cases. The other 70 percent of autism cases are believed to be caused by mutations of genetics and environmental factors combined.

Although many individuals with autism go on to live normal productive lives, 35 percent of young adults with the disorder are unable to work jobs or pursue higher education after high school.

Doctors currently rely on a series of behavioral tests to diagnose the disorder. These can take a great deal of time and are not always accurate. If a blood or urine test could provide a faster and more definitive diagnosis, it would go a long way to ensure young children received the treatment and resources they need earlier on.

However, although experts see the new research as promising, they are still cautioning that such a test is still a long way from being viable.

>> Related: Possible autism breakthrough using children’s own stem cells 

"This is a promising area; however, this is a very long way indeed from a 'test for autism,' " Dr. Max Davie, spokesman for the Royal College of Paediatrics and Child Health, said. "It is important that it is not adopted with too much enthusiasm."

Reader Comments ...

Next Up in Nation & World

Florida Gov. Rick Scott signs year-round daylight saving time measure
Florida Gov. Rick Scott signs year-round daylight saving time measure

Florida Gov. Rick Scott is signing off on a measure that would let Florida stay on daylight saving time all year long. >> Read more trending news  Scott on Friday signed 74 bills into law, including the "Sunshine Protection Act." The measure won't take effect unless Congress also changes federal law. But if Congress were to go...
Mother crashed car into pole to prove to kids God is real, police say
Mother crashed car into pole to prove to kids God is real, police say

Police say a mother intentionally crashed her SUV into a pole to prove to her two small children that God is real. >> Read more trending news  Investigators say Bakari Warren, 25, told officers after the crash that she did it on purpose to show her kids that if they believe, God would protect them. The crash and the 5- and 7-year-old kids&rsquo...
Cyberattack on City of Atlanta could compromise sensitive information
Cyberattack on City of Atlanta could compromise sensitive information

City of Atlanta officials are struggling to determine how much sensitive information may have been compromised in a Thursday cyber attack. >> Read more trending news  They urged employees to check their bank accounts to make sure their financial information had not been accessed and said that anyone who had conducted transactions with the...
12-year-old boy missing after getting on wrong school bus has been found near his home
12-year-old boy missing after getting on wrong school bus has been found near his home

Update March 23, 2018 8:50 EST: A missing Atlanta area middle schooler has been found safe. Anthony Randolph III disappeared Wednesday after getting on the wrong bus at his school in DeKalb, Georgia. Investigators have been searching for the boy for two days and found him Friday at a gas station not far from his home, police said. Police have not released...
Soaps and paint pollute air as much as car emissions, study shows
Soaps and paint pollute air as much as car emissions, study shows

For many years, motor vehicle emissions were the primary source of air pollution in urban areas. But with increased regulations and better engines, that has changed. While industry professionals and government leaders worked to address pollution from cars, little notice was given to the effects of other commonly used consumer products. Now...
More Stories